This Month’s Focus: Tableting
Flashing during tablet compression
Flashing is a common problem for manufacturers of pharmaceutical and nutraceutical tablets. This article explains what causes flashing and provides measures you can take to prevent it.
Advantages of using an instrumented R&D tablet press
This article discusses the value that an instrumented tablet press can provide during the research and development phase of a tablet manufacturing process.
Cannabis manufacturer upgrades tableting equipment to improve product quality
Dixie Brands, Denver, CO, manufactures and distributes products infused with tetrahydrocannabinol (THC) and cannabidiol (CBD). These products include several lines of mints, which must be manufactured to a specific target hardness to maintain structural integrity while remaining soft enough for consumers to chew. The machinery that Dixie had been using to manufacture the mints could not provide consistent tablet weight or hardness across product batches, resulting in overly soft, poor-quality tablets, so the company reached out to tableting equipment supplier, Elizabeth, for assistance.
Eye on Excipients: Lubricants in direct-compression tableting
This edition of Eye on Excipients discusses direct-compression tableting and describes the benefits and limitations of two direct-compression lubricants.
Developing combination drug products using liquid-filled hard-shell capsules
This article describes the benefits of liquid-filled hard-shell capsules for combination products, discusses the factors to consider during capsule selection, and provides examples of currently marketed combinations and potential candidates for development.
Blending and tablet compression: Tablet hardness
This article is the second in a two-part series discussing how blending practices can influence tablet compression. In part one (July 2019), the author explained how percolation of air entrapped in a formulation during blending influences material flow. Part two discusses how blending can influence tablet hardness.
Pack Expo Las Vegas preview
Pack Expo Las Vegas—a trade show focused on the latest advances in packaging equipment, materials, and containers—will take place September 23 to 25 at the Las Vegas Convention Center. The show is co-located with Healthcare Packaging Expo, and organizers expect more than 30,000 attendees and 2,000 suppliers from the pharmaceutical, medical device, and food and beverage industries.
Back Page: How proposed EU microplastics legislation could impact the pharma industry
Concern about microplastics has been growing for some time, particularly in Europe. Historically, microplastics contamination of the marine environment has been attributed to factors such as large plastic wastes, scrubbing agents in toiletries, tire erosion, and abrasion of synthetic textiles during washing. Pharmaceutical and excipient manufacturers generally haven’t viewed microplastics as an issue that would significantly impact medicinal products. That changed in January of this year when the European Chemicals Agency (ECHA) issued a proposal to restrict the use of intentionally added microplastics (Annex XV Restriction Report).
Excipient-related FDA warning letters
January: Capsule Filling
June: Solid Dosage Sourcebook
July: Excipients & Formulation
October: Quality, Validation & Regulatory Compliance
November: Annual Buyer’s Guide
Tablets & Capsules Technical Article GuidelinesTablets & Capsules is the world’s only publication dedicated to solid dosage forms. Our readers are the people responsible for the formulation, production, and packaging of pharmaceutical and nutraceutical tablets and capsules in North America. Each issue reaches about 10,000 readers whose job functions include R&D, QC, engineering, and operations. All are technical decision-makers who need practical information.
T&C’s technical articles are written by technical professionals for technical professionals. But they are a collaborative effort: You provide the content and expertise, and T&C’s editors tailor your article to T&C’s audience.
For sample topics and details on how to submit an article and share your expertise, download the full technical article guidelines below or contact the editor.
2. Multi-layer Tableting
2. Powder Transfer & Containment
2. Mixers & Blenders
2. Tablet & Capsule Identification