Cover Photo Courtesy of
Gattefossé

A look at how the COVID-19 pandemic has impacted the pharmaceutical supply chain and how companies must adapt to succeed in this new business environment.

In this article, scientists at Metrics Contract Services developing a roller-compacted tablet formulation troubleshoot a powder-binding problem they encounter when scaling up the manufacturing process from proof-of-concept scale to pilot scale.

This article describes how technological advances have made plant-based hard-capsules an attractive alternative to traditional gelatin hard capsules, offering enhanced technical and cultural compatibility and allowing formulators to develop innovative patient-centric medicines.

Encountering dissolution problems during scale-up of a tablet product can be frustrating and lead to a costly delay in the product’s time to market. However, a careful investigation of the materials and equipment and a thorough understanding of the process can minimize delays and help to ensure a successful product launch.

Content uniformity is critical to the quality and performance of solid oral drug products. This article describes a study conducted to mitigate segregation of an example drug formulation during filling and discharge from a typical batch feeding process to ensure content uniformity of the final product. While the material and equipment discussed in this article are for a pharmaceutical application, the same principles apply to the nutraceutical, food, chemical, powdered metal, ceramic, and cosmetic industries.

This article details how to perform an out-of-specification investigation for dietary supplement products.

Continuous direct compression (CDC) tableting offers several key technical and process advantages over traditional batch tableting processes. First and foremost, it allows the manufacturer to develop a drug product on the same equipment drivetrain that will be used for the product’s final manufacture, eliminating process scale-up. CDC tableting also allows for increased quality assurance and requires less production space, which lowers utility and labor costs.

In this article, experts describe the benefits of the Tableting Specification Manual to tablet manufacturers and equipment suppliers and discuss aspects of the manual that may be due for an update.