This Month’s Focus: Excipients & Formulation
COVID-19 and the pharmaceutical supply chain
A look at how the COVID-19 pandemic has impacted the pharmaceutical supply chain and how companies must adapt to succeed in this new business environment.
Preventing powder binding during scale-up of a roller-compacted tablet formulation
In this article, scientists at Metrics Contract Services developing a roller-compacted tablet formulation troubleshoot a powder-binding problem they encounter when scaling up the manufacturing process from proof-of-concept scale to pilot scale.
Plant-based hard capsules: A new era for patients and drug developers
This article describes how technological advances have made plant-based hard-capsules an attractive alternative to traditional gelatin hard capsules, offering enhanced technical and cultural compatibility and allowing formulators to develop innovative patient-centric medicines.
Back Page: What to do if your immediate-release tablet scale-up batch fails dissolution
Encountering dissolution problems during scale-up of a tablet product can be frustrating and lead to a costly delay in the product’s time to market. However, a careful investigation of the materials and equipment and a thorough understanding of the process can minimize delays and help to ensure a successful product launch.
Mitigating segregation in batch feed systems
Content uniformity is critical to the quality and performance of solid oral drug products. This article describes a study conducted to mitigate segregation of an example drug formulation during filling and discharge from a typical batch feeding process to ensure content uniformity of the final product. While the material and equipment discussed in this article are for a pharmaceutical application, the same principles apply to the nutraceutical, food, chemical, powdered metal, ceramic, and cosmetic industries.
Spotlight on Nutraceuticals: How to perform an out-of-specification investigation
This article details how to perform an out-of-specification investigation for dietary supplement products.
Gravimetric feeders support Eli Lilly’s advancements in continuous direct-compression tableting
Continuous direct compression (CDC) tableting offers several key technical and process advantages over traditional batch tableting processes. First and foremost, it allows the manufacturer to develop a drug product on the same equipment drivetrain that will be used for the product’s final manufacture, eliminating process scale-up. CDC tableting also allows for increased quality assurance and requires less production space, which lowers utility and labor costs.
A common vocabulary: The Tableting Specification Manual’s role in an ever-changing industry
In this article, experts describe the benefits of the Tableting Specification Manual to tablet manufacturers and equipment suppliers and discuss aspects of the manual that may be due for an update.
Minitablets & microtip tooling
January: Capsule Filling
June: Solid Dosage Sourcebook
July: Excipients & Formulation
October: Quality, Validation & Regulatory Compliance
November: Annual Buyer’s Guide
Tablets & Capsules Technical Article GuidelinesTablets & Capsules is the world’s only publication dedicated to solid dosage forms. Our readers are the people responsible for the formulation, production, and packaging of pharmaceutical and nutraceutical tablets and capsules in North America. Each issue reaches about 10,000 readers whose job functions include R&D, QC, engineering, and operations. All are technical decision-makers who need practical information.
T&C’s technical articles are written by technical professionals for technical professionals. But they are a collaborative effort: You provide the content and expertise, and T&C’s editors tailor your article to T&C’s audience.
For sample topics and details on how to submit an article and share your expertise, download the full technical article guidelines below or contact the editor.
2. Multi-layer Tableting
2. Powder Transfer & Containment
2. Mixers & Blenders
2. Tablet & Capsule Identification