This article describes a streamlined approach to generating clinical formulations for poorly soluble compounds using milligram quantities of API. The article includes a case study in which formulators quickly determine the optimal formulation and manufacturing method for a particularly challenging drug candidate, enabling advancement to clinical trials.

This article provides guidance to help formulators develop solid oral drug products using complex active pharmaceutical ingredients (APIs).

Parsolex is a contract development and manufacturing services organization (CDMO) that works with clients involved in the research, development, and commercialization of non-sterile pharmaceutical products. The company’s clients include small, large, and virtual pharmaceutical companies; research universities; clinical research organizations; and hospitals.

In the pharmaceutical industry, batch manufacturing has long been standard practice. Making batches bigger drove down unit cost because of high fixed costs on a per-batch basis. Historically, market demand has supported this strategy, but bigger batch sizes are no longer better. As blockbuster drugs lose patent protections—and sponsors, distributors, and patients seek ever-greater flexibility in terms of access, cycle times, and cost—the pharmaceutical industry is moving toward smaller batch processing.

Building brand equity and driving organic growth continues to be a challenge for marketers of oral consumer healthcare products, including both over-the-counter (OTC) drug products and vitamin, mineral, and dietary supplement (VMS) products. This article reviews the benefits of novel oral drug delivery systems to product performance and user satisfaction and provides examples of brands that have successfully incorporated new drug delivery systems into their product lines.

This article discusses the benefits of using product-specific slats on solid dosage bottle-filling machines, including increasing fill accuracy and rate, decreasing product loss, and speeding the bottling process.

Capsule manufacturers consider many factors when designing and producing hard capsules. Consumer trends are often key considerations, and the industry seeks to accommodate niche demands and cater to small market populations. Although gelatin-based hard capsules continue to dominate the hard-capsule market, use of plant-based hard capsules is growing quickly due to the demands of vegans and vegetarians.