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Tablets & Capsules SDD

imageIn this issue of T&C Solid Dose Digest:

 
 
 
 
 
 
 
Letter from Nate Todd,
editor of Tablets & Capsules
 
While the term "social distancing" is likely to make every Words of the Year list for 2020, the global COVID-19 pandemic has brought into sharp relief just how closely connected and interdependent we really are. Industries and jobs that many of us took for granted are being recognized as essential to the health and wellbeing of a functioning society. For every disheartening story we hear about toilet paper hoarding or so-called "coronavirus parties" being held in defiance of social distancing orders, we hear several uplifting stories about regular people demonstrating courage and compassion to help ease the suffering of fellow citizens and slow the virus' spread.
 
 
Wilson

CapsCanada
 
Ask an Expert
 
TiO2 replacement in tablet film coating
 
Q: What are the natural white pigments that can replace titanium dioxide, and how easy is it to reformulate an existing film coating?
 
 
imageTitanium dioxide (TiO2), commonly referred to as E171, is widely used as a whitening agent and is one of the most important food additives in nutraceuticals. Consumer concerns about TiO2 stem from several disputed studies that described a potential risk to the human respiratory system from TiO2 nanoparticles [1]. Potential risks exist because TiO2 nanoparticles may accumulate after inhalation or oral exposure in the lungs, alimentary tract, liver, heart, spleen, kidneys, and cardiac muscle.
 
 
 
USP

Gelita
 
More Questions and Answers
 
Vendor-supplied tablet drawings
 
Q: What can we learn from vendor-supplied tablet drawings?
 
A: John Norman and Bill Turner, Natoli Engineering, say:
 
imageUpon request, reputable tooling vendors can supply you with highly accurate tablet and tooling drawings that include comprehensive information about each of your drug products. These drawings identify the unique properties of a tablet design. Most tooling vendors use a standard drawing format, or title block, for each drawing. The title block includes the tablet's description, recommended maximum compression force ratings for tooling, engineering data, and other information.
 
 
 
Natoli

MFG Tray Co
 
In Tablets & Capsules magazine
 
CDMO turns to rotary granulation process to solve complex reformulation challenge
 
 
Recro Gainesville is a contract development and manufacturing organization (CDMO) that provides oral solid dosage (OSD) form development, regulatory support, clinical and commercial manufacturing, and packaging and logistics services to the global pharmaceutical market. Based in Gainesville, GA, the company operates facilities totaling 120,000 square feet and specializes in modified-release OSD products and DEA-controlled substances.
 
Recently, a new customer asked the CDMO to reformulate an immediate-release OSD with a dosing regimen of 3 times per day to create an extended-release product with a complex release profile and a dosing regimen of twice per day. Drug product manufacturers often want to reformulate multidose products into once- or twice-daily dosage forms because reducing the dosing regimen can increase patient convenience and adherence and may also reduce potential side effects.
 
To learn more about this topic, you can read the article "CDMO turns to rotary granulation process to solve complex reformulation challenge." You can also find articles under "Dosage form," "Formulation," "Granulation," and "Outsourcing" in Tablets & Capsules' Article Archive.
 
 
Ackley

Camfil
 
Industry news
 
 
 
 
 
 
 
 
 
Camfil

Vac-U-Max
 
Supplier news
 
 
 
To find more information about suppliers at the Tablets & Capsules website, click here.
 
 
Vac-U-Max

elizabeth
 
Events and continuing education
 
Please check event websites for the most up-to-date information, because conferences and seminars may be canceled or postponed due to the developing COVID-19 pandemic.
 
 
 
 
 
 
 
To find more events and continuing education opportunities at the Tablets & Capsules website, click here.
 

TC Article Archive
April 20, 2020
 
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Supplier Resources
click below for more info
 
Vac-U-Max
 
Wilson
 
Ackley
 
Camfil
 
Camfil
 
Camfil
 
CapsCanada
 
Gelita
 
MFG Tray
 
elizabeth
 
Natoli
 
USP
 
Supplier Directory
 
Anti-Counterfeiting
Ackley Machine

Capsule Filling Equipment
Natoli Engineering
Vac-U-Max

Contract Formulation/
Manufacturing & Packaging

CapsCanada

Conveying/Mechanical
VAC-U-MAX

Dedusters
Elizabeth Scheu & Kniss
Natoli Engineering

Dust Collectors
Camfil APC
Elizabeth Scheu & Kniss

Empty Capsules
CapsCanada
Embocaps by Suheung

Excipients
CapsCanada
USP

Feeders
Ackley Machine
Elizabeth Scheu & Kniss

Inspection Equipment
Ackley Machine
Elizabeth Scheu & Kniss
Natoli Engineering

Metal Detectors/X-Ray Detectors
Elizabeth Scheu & Kniss
Natoli Engineering

Packaging Equipment
Ackley Machine
Elizabeth Scheu & Kniss
VAC-U-MAX

Pneumatic Conveying
VAC-U-MAX

Services
Ackley Machine
CapsCanada
Elizabeth Scheu & Kniss
Natoli Engineering

Softgels
Ackley Machine
MFG Tray Company

Storage/Bulk Handling
MFG Tray Company
VAC-U-MAX

Tablet & Capsule Printers
Ackley Machine
CapsCanada

Tablet Presses
Elizabeth Scheu & Kniss
KORSCH
Natoli Engineering

Testing
Natoli Engineering

Tooling
Elizabeth Scheu & Kniss
KORSCH
Natoli Engineering
Wilson Tool

Vacuum Cleaners
VAC-U-MAX

Validation
USP

Weighing Equipment
VAC-U-MAX
 
T&C Solid Dosage Sourcebook
 
sourcebook

Send your feedback or questions to Peggy Wright at pwright@cscpub.com.
Peggy Wright
T&C Solid Dose Digest
Editor
pwright@cscpub.com
 
Kyle Myers
T&C Solid Dose Digest
Circulation
kmyers@cscpub.com
 
Kurt Beckman
T&C Solid Dose Digest
Designer
kbeckman@cscpub.com
 
Nate Todd
Tablets & Capsules
Editor
ntodd@cscpub.com
 
 
 
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