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Tablets & Capsules SDD

imageIn this issue of T&C Solid Dose Digest:

 
 
 
 
 
 
 
Camfil

Vac-U-Max
 
Ask an Expert
 
Loading formulation into a tablet press or encapsulator
 
Q: What are our options for charging a tablet press or encapsulator?
 
 
imageA common oversight when purchasing a new tablet press or encapsulator is failing to purchase the means to charge it with the formulation. Manufacturers often find that they must raise drums of drug product with an unsanitary fork truck in the process area and then have an operator on a ladder scoop it into the infeed hopper.
 
 
 
Wilson

CapsCanada
 
More Questions and Answers
 
Industry standards for two-piece capsules
 
Q: How does the lack of industry standards for the dimensions of empty two-piece capsules and associated filling equipment affect pharmaceutical and nutritional product manufacturing?
 
 
imageNo set industry standards exist for the dimensions of either gelatin or HPMC, two-piece capsules or for the specifications of the equipment used to fill them. Upon their development, HPMC capsules didn't even match the sizes of gelatin capsules from the same manufacturer, making their introduction even more difficult.
 
 
 
USP

Gelita
 
In Tablets & Capsules magazine
 
Using multivariate analysis of batch-to-batch excipient variation to reduce risk
 
H. L. Blaauw, B. H. J. Dickhoff, T. Schigt, and A. W. van Gessel, DFE Pharma
 
This article describes the batch-to-batch variation of a multiyear excipient production data set and the subsequent impact of the variation observed on the excipient's processability and/or functionality. This type of consistency data can help drug product manufacturers assess the risks associated with using specific grades of excipients and/or vendors for their products.
 
In the pharmaceutical industry, a detailed understanding of the impact of raw material variation on a drug product's performance and manufacturing is key [1]. Drug products consist of an active pharmaceutical ingredient (API) as well as many functional excipients. The functional excipients enable the API to be processed into a final dosage form and may also enhance stability, bioavailability, or patient acceptance [2]. While the impact of API variability (such as particle size, morphology, or purity) on a drug product is evident, studies are increasingly showing the importance of considering the variation in functional excipients used in formulations as well [2-6].
 
To learn more about this topic, you can read the article "Using multivariate analysis of batch-to-batch excipient variation to reduce risk." You can also find articles under "Excipients," "Quality assurance," and "Quality by Design (QbD)" in Tablets & Capsules' Article Archive.
 
 
Natoli

MFG Tray Co
 
Industry news
 
 
 
 
 
 
 
 
Ackley

exipient world
 
Supplier news
 
 
 
To find more information about suppliers at the Tablets & Capsules website, click here.
 
 
Events and continuing education
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
To find more events and continuing education opportunities at the Tablets & Capsules website, click here.
 
February 10, 2020
 
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Supplier Resources
click below for more info
 
CapsCanada
 
Gelita
 
MFG Tray
 
Natoli
 
USP
 
Vac-U-Max
 
Wilson
 
Ackley
 
Camfil
 
Supplier Directory
 
Anti-Counterfeiting
Ackley Machine

Capsule Filling Equipment
Natoli Engineering
Vac-U-Max

Contract Formulation/
Manufacturing & Packaging

CapsCanada

Conveying/Mechanical
VAC-U-MAX

Dedusters
Natoli Engineering

Dust Collectors
Camfil APC

Empty Capsules
CapsCanada

Excipients
CapsCanada
USP

Feeders
Ackley Machine

Inspection Equipment
Ackley Machine
Natoli Engineering

Metal Detectors/X-Ray Detectors
Natoli Engineering

Packaging Equipment
Ackley Machine
VAC-U-MAX

Pneumatic Conveying
VAC-U-MAX

Services
Ackley Machine
CapsCanada
Natoli Engineering

Softgels
Ackley Machine
MFG Tray Company

Storage/Bulk Handling
MFG Tray Company
VAC-U-MAX

Tablet & Capsule Printers
Ackley Machine
CapsCanada

Tablet Presses
Natoli Engineering

Testing
Natoli Engineering

Tooling
Natoli Engineering
Wilson Tool

Vacuum Cleaners
VAC-U-MAX

Validation
USP

Weighing Equipment
VAC-U-MAX
 
T&C Solid Dosage Sourcebook
 
sourcebook

Send your feedback or questions to Peggy Wright at pwright@cscpub.com.
Peggy Wright
T&C Solid Dose Digest
Editor
pwright@cscpub.com
 
Kyle Myers
T&C Solid Dose Digest
Circulation
kmyers@cscpub.com
 
Kurt Beckman
T&C Solid Dose Digest
Designer
kbeckman@cscpub.com
 
Nate Todd
Tablets & Capsules
Editor
ntodd@cscpub.com
 
 
 
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