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Tablets & Capsules SDD

imageIn this issue of T&C Solid Dose Digest:

 
 
 
 
 
 
 
Ackley

Camfil
 
Ask an Expert
 
Automating manual operations
 
Q: How do I know if it's time to automate manual operations in tablet filling and packaging?
 
A: John Deitz, Deitz, says:
 
imageYou usually don't have to upgrade your entire filling line from manual or semiautomated to fully automated operations all at once. You can automate one or a few operations at a time, with a plan to add more as the company grows and production increases and as the budget allows.
 
 
 
Vac-U-Max

Wilson
 
Feature
 
A systematic approach to solving encapsulation problems caused by a sticky formulation
 
A: Jon Carlisle, Natoli Engineering, says:
 
This article provides a best-practices approach to troubleshooting capsule-filling problems when handling a sticky drug product formulation.
 
A sticky formulation is one of the most common causes of problems during capsule filling. A capsule filler requires tight tolerances between the machine's tooling components, including the dosing disks, tamping pins, and sealing plate, as well as between the capsules and the bores of the segments, which hold the capsules during filling. Friction between the formulation and these tooling components during high-speed operation can cause a sticky formulation to cake and glaze onto the tooling surfaces, restricting the components' movement and leading to inconsistent capsule weights, capsule splits, non-separation, and even machine crashes.
 
Manufacturers often hope for a silver-bullet approach—one single solution that will fix every sticky formulation issue—but the solution is rarely that simple. Several factors often combine to cause a material to stick, and the problem is best solved using a systematic approach.
 
To learn more about this topic, you can read the article "A systematic approach to solving encapsulation problems caused by a sticky formulation." You can also find articles under "Capsules and Capsule Filling" in Tablets & Capsules' Article Archive.
 

 
Jon Carlisle, Natoli Engineering, St. Charles, MO. The company manufactures tablet press replacement parts, tablet compression tooling, and tablet presses and offers the largest selection of tablet compression accessories in the industry. For more information, contact the company.
 
 
CapsCanada

USP
 
In Tablets & Capsules magazine
 
Dry binders in direct-compression tablet formulations
 
Javier Camargo and Carolina Diaz Quijano, Omya International
 
This article discusses the pros and cons of direct-compression tableting and describes a study conducted to test the benefits of adding dry binders to direct-compression tablet formulations.
 
Compressed tablets continue to be the most popular pharmaceutical dosage form [1]. They provide higher content uniformity and are easier to administer at home than syrups or suspensions. They also provide superior chemical, microbiological, and mechanical stability when compared to other solid dosage forms, such as lyophilized tablets. Additionally, compressed tablets are the most cost-efficient dosage form, as they are easier to transport and store than other forms and can also be designed for fast disintegration (ODTs) and immediate, delayed, or targeted drug release.
 
Compressed tablets can be made using a wet-granulation process followed by compression or simply by direct compression (DC). DC tableting has been steadily increasing in acceptance and use since the 1960s, when the first excipients suitable for DC tableting were developed [2].
 
To learn more about this topic, you can read the article "Eye on Excipients: Dry binders in direct-compression tablet formulations." You can also find articles under "Excipients," "Formulation," and "Tablets and tabletting" in Tablets & Capsules' Article Archive.
 
 
Gelita

Natoli
 
Industry news
 
 
 
 
 
 
 
 
MFG Tray Co

tc
 
Supplier news
 
 
 
 
 
To find more information about suppliers at the Tablets & Capsules website, click here.
 
 
Events and continuing education
 
 
 
 
 
 
 
 
 
 
 
 
To find more events and continuing education opportunities at the Tablets & Capsules website, click here.
 
January 27, 2020
 
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Supplier Resources
click below for more info
 
Camfil
 
CapsCanada
 
Gelita
 
MFG Tray
 
Natoli
 
USP
 
Vac-U-Max
 
Wilson
 
Ackley
 
Supplier Directory
 
Anti-Counterfeiting
Ackley Machine

Capsule Filling Equipment
Natoli Engineering
Vac-U-Max

Contract Formulation/
Manufacturing & Packaging

CapsCanada

Conveying/Mechanical
VAC-U-MAX

Dedusters
Natoli Engineering

Dust Collectors
Camfil APC

Empty Capsules
CapsCanada

Excipients
CapsCanada
USP

Feeders
Ackley Machine

Inspection Equipment
Ackley Machine
Natoli Engineering

Metal Detectors/X-Ray Detectors
Natoli Engineering

Packaging Equipment
Ackley Machine
VAC-U-MAX

Pneumatic Conveying
VAC-U-MAX

Services
Ackley Machine
CapsCanada
Natoli Engineering

Softgels
Ackley Machine
MFG Tray Company

Storage/Bulk Handling
MFG Tray Company
VAC-U-MAX

Tablet & Capsule Printers
Ackley Machine
CapsCanada

Tablet Presses
Natoli Engineering

Testing
Natoli Engineering

Tooling
Natoli Engineering
Wilson Tool

Vacuum Cleaners
VAC-U-MAX

Validation
USP

Weighing Equipment
VAC-U-MAX
 
T&C Solid Dosage Sourcebook
 
sourcebook

Send your feedback or questions to Peggy Wright at pwright@cscpub.com.
Peggy Wright
T&C Solid Dose Digest
Editor
pwright@cscpub.com
 
Kyle Myers
T&C Solid Dose Digest
Circulation
kmyers@cscpub.com
 
Kurt Beckman
T&C Solid Dose Digest
Designer
kbeckman@cscpub.com
 
Nate Todd
Tablets & Capsules
Editor
ntodd@cscpub.com
 
 
 
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