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Tablets & Capsules SDD
imageIn this issue of T&C Solid Dose Digest:
 
 
 
 
 
 
 
vacumax

recro
 
Ask an Expert
 
Defining clean label
 
Q: What does clean label mean to the dietary supplement industry and to consumers?
 
A: Steve Peirce, Ribus, says:
 
imageConsumer demand and global trends greatly impact the dietary supplement industry. Consumers are inundated with marketing information from brands but are increasingly looking beyond marketing and demanding transparency. Savvy consumers have made the connection between food as nutrition and dietary supplements as nutrition and desire the same clean labels for dietary supplements that they have for food. Consumers simply want to understand if a product is pure, and this knowledge is motivating their purchasing habits.
 
 
 
kikusui

camfilapc
 
More Questions and Answers
 
Dark spots in tablets
 
Q: How do I determine the cause of dark spots in my tablets during production and prevent them from occurring?
 
A: John Norman, Natoli Engineering, says:
 
imageDark spots are common defects that arise during tablet manufacturing, and determining their primary cause can be difficult. The first step in troubleshooting dark spots is to determine where the spots are located on the tablets.
 
Split a tablet to determine whether the spots occur throughout the tablet or just on the surface. If dark spots are present in the tablet's interior, the cause is likely an issue in a process upstream from the tablet press, such as blending.
 
 
 
jrs pharma

gelita
 
In Tablets & Capsules magazine
 
Calcium phosphates in direct-compression tableting
 
Tobias Hess, Marek Lachmann, and Daniel Zakowiecki, Budenheim
 
This article describes the benefits of using calcium phosphate excipients in direct-compression (DC) tableting applications and compares several DC calcium phosphate types.
 
The pharmaceutical industry has been using calcium salts of orthophosphoric acid (calcium phosphates) for many years. Calcium phosphates possess many physical and chemical properties that make them ideal candidates for use as excipients in solid oral dosage formulations. Until recently, they were considered inactive ingredients used only as fillers/diluents to bulk up formulations and facilitate their further processing [1]. Their functionality goes far beyond being a mere filler, however, and when used appropriately, they can help improve drug product efficacy as well as long-term stability.
 
Calcium phosphates are inorganic substances of mineral origin and are, therefore, characterized by exceptional chemical stability. For the same reason, they are compatible with most known drug substances. A few exceptions include indomethacin and tetracycline antibiotics, which combine with the calcium ions to form poorly soluble complexes. Also, tribasic calcium phosphate (USP monograph) is incompatible with tocopheryl acetate due to the large number of hydroxyl groups on the surface of the substance [1, 2].
 
To learn more about this topic, you can read the article "Eye on Excipients: Calcium phosphates in direct-compression tableting." You can also find articles under "Excipients" in Tablets & Capsules' Article Archive.
 
 
mfgtray

wilson
 
Industry news
 
 
 
 
 
 
jost

natoli
 
Supplier news
 
 
 
To find more information about equipment suppliers at the Tablets & Capsules website, click here.
 
 
nilfisk

tc
 
Events and continuing education
 
 
 
 
 
 
 
 
 
 
To find more events and continuing education opportunities at the Tablets & Capsules website, click here.
 
October 28, 2019
 
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Supplier Resources
click below for more info
 
jrs pharma
 
jost
 
wilson
 
gelita
 
camfil
 
mfgtray
 
kikusui
 
vacumax
 
recro
 
nilfisk
 
natoli
 
Supplier Directory
 
Capsule Filling Equipment
Vac-U-Max

Coating
(Equipment & Coatings)

JRS Pharma

Contract Formulation/
Manufacturing & Packaging

Recro Gainesville

Conveying/Mechanical
VAC-U-MAX

Dedusters
Natoli Engineering

Dust Collectors/Filters
Camfil APC
Nilfisk Industrial Vacuums
VAC-U-MAX

Excipients
Gelita
Jost Chemical
JRS Pharma

Feeders
VAC-U-MAX

Inspection Equipment
Natoli Engineering

Lifters
VAC-U-MAX

Metal Detectors/X-Ray Detectors
Natoli Engineering

Mixers & Blenders
VAC-U-MAX

Pneumatic Conveying
Nilfisk Industrial Vacuums
VAC-U-MAX

Services
Natoli Engineering
VAC-U-MAX
Wilson Tool

Softgels
MFG Tray Company

Storage/Bulk Handling
MFG Tray Company
VAC-U-MAX

Tablet Presses
Kikusui USA Inc.
Natoli Engineering

Testing Equipment
Natoli Engineering

Tooling
Natoli Engineering
Wilson Tool

Vacuum Cleaners
Nilfisk Industrial Vacuums
VAC-U-MAX

Weighing Equipment
VAC-U-MAX
 
T&C Solid Dosage Sourcebook
 
sourcebook

Send your feedback or questions to Peggy Wright at pwright@cscpub.com.
Peggy Wright
T&C Solid Dose Digest
Editor
pwright@cscpub.com
 
Kyle Myers
T&C Solid Dose Digest
Circulation
kmyers@cscpub.com
 
Kurt Beckman
T&C Solid Dose Digest
Designer
kbeckman@cscpub.com
 
Nate Todd
Tablets & Capsules
Editor
ntodd@cscpub.com
 
 
 
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