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Tablets & Capsules SDD
imageIn this issue of T&C Solid Dose Digest:
 
 
 
 
 
 
 
natoli

nilfisk
 
More Questions and Answers
 
Tablet weight
 
Q: How can I ensure that my tablet press accurately fills the dies with powder?
 
A: Robert Sedlock, Natoli Engineering, says:
 
imageTo produce high-quality tablets, you must understand the factors that influence a tablet's critical quality attributes. One crucial factor is the final tablet weight. Tablet weight not only impacts the amount of active ingredient in the tablet but also directly affects the amount of compression force the tablet press will apply and the resulting tablet strength, friability, disintegration, and dissolution time.
 
 
 
vacumax

recro
 
In Tablets & Capsules magazine
 
Improving cost efficiency and flexibility in tablet coating processes
 
Torsten Meinel-Dirumdam, Lödige
 
Pharmaceutical manufacturers face high demands for both cost efficiency and flexibility. This article discusses ways modern production coating equipment addresses these demands without sacrificing coating quality, including speeding up tablet discharge, easily adapting to process changes, and providing automated, effective cleaning.
 
To succeed in today's demanding pharmaceutical manufacturing environment, a tablet coating process must be as efficient as possible. This means that each step or aspect of the coating process must be optimized to suit the requirements of the specific product being coated, including how the tablets are fed into and discharged from the coater and how the coater is cleaned between batches or products. Optimizing each of these steps will minimize process time and ensure high-quality coated tablets despite variations in batch size or the depth of the tablet bed in the coating drum.
 
To learn more about this topic, you can read the article "Improving cost efficiency and flexibility in tablet coating processes." You can also find articles under "Tablet coating" in Tablets & Capsules' Article Archive.
 
 
kikusui

camfilapc
 
Feature
 
Identifying and mitigating unwanted particle breakage
 
 
This article explains how to test for, quantify, and mitigate unwanted particle breakage in bulk solids handling processes
 
Engineers often design a process specifically to create a mixture of particles with a prescribed size, shape, porosity, and chemical consistency only to find that subsequent handling and processing breaks the particles, altering their characteristics. Such unwanted particle breakage is a serious challenge for many industries that use bulk powders and can cause problems for packaging, creating unit doses, or customer acceptance.
 
In pharmaceutical tableting processes, unwanted particle breakage can lead to segregation, weight variation, and poor compaction, resulting in 10 to 20 percent product loss during a production run or time-to-market delays as engineers attempt to fix the problem and pass process validation requirements. Time-to-market delays can cost a pharmaceutical company millions or even billions of dollars, depending on the drug product. Particle breakage can also cause a free-flowing material to become cohesive and hang up in process vessels, which may require expensive retrofits to ensure adequate flow.
 
In this article, I'll provide a systematic and science-based approach for solving, or at least understanding, the problem of unwanted particle breakage.
 
For more information on this topic, you can read the article "Identifying and mitigating unwanted particle breakage," by Kerry Johanson, Material Flow Solutions. You can also find articles listed under "Analytical techniques" in Tablets & Capsules'
 
 
jrs pharma

gelita
 
Industry news
 
 
 
 
 
 
 
mfgtray

wilson
 
Supplier news
 
 
 
To find more information about equipment suppliers at the Tablets & Capsules website, click here.
 
 
jost

tc
 
Events and continuing education
 
 
 
 
 
 
 
 
 
 
To find more events and continuing education opportunities at the Tablets & Capsules website, click here.
 
September 23, 2019
 
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Supplier Resources
click below for more info
 
nilfisk
 
natoli
 
jrs pharma
 
jost
 
wilson
 
gelita
 
camfil
 
mfgtray
 
kikusui
 
vacumax
 
recro
 
Supplier Directory
 
Capsule Filling Equipment
Vac-U-Max

Coating
(Equipment & Coatings)

JRS Pharma

Contract Formulation/
Manufacturing & Packaging

Recro Gainesville

Conveying/Mechanical
VAC-U-MAX

Dedusters
Natoli Engineering

Dust Collectors/Filters
Camfil APC
Nilfisk Industrial Vacuums
VAC-U-MAX

Excipients
Gelita
Jost Chemical
JRS Pharma

Feeders
VAC-U-MAX

Inspection Equipment
Natoli Engineering

Lifters
VAC-U-MAX

Metal Detectors/X-Ray Detectors
Natoli Engineering

Mixers & Blenders
VAC-U-MAX

Pneumatic Conveying
Nilfisk Industrial Vacuums
VAC-U-MAX

Services
Natoli Engineering
VAC-U-MAX
Wilson Tool

Softgels
MFG Tray Company

Storage/Bulk Handling
MFG Tray Company
VAC-U-MAX

Tablet Presses
Kikusui USA Inc.
Natoli Engineering

Testing Equipment
Natoli Engineering

Tooling
Natoli Engineering
Wilson Tool

Vacuum Cleaners
Nilfisk Industrial Vacuums
VAC-U-MAX

Weighing Equipment
VAC-U-MAX
 
T&C Solid Dosage Sourcebook
 
sourcebook

Send your feedback or questions to Peggy Wright at pwright@cscpub.com.
Peggy Wright
T&C Solid Dose Digest
Editor
pwright@cscpub.com
 
Kyle Myers
T&C Solid Dose Digest
Circulation
kmyers@cscpub.com
 
Kurt Beckman
T&C Solid Dose Digest
Designer
kbeckman@cscpub.com
 
Nate Todd
Tablets & Capsules
Editor
ntodd@cscpub.com
 
 
 
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