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Tablets & Capsules SDD
imageIn this issue of T&C Solid Dose Digest:
 
 
 
 
 
 
 
gelita

wilson
 
Ask an Expert
 
Microdosing ingredients
 
Q: What factors should we consider when microdosing APIs and excipients?
 
 
image Four factors determine the best solutions for microdosing:
  1. The active pharmaceutical ingredients (APIs) and/or excipients you're handling;
  2. The intended use of the process—for R&D only or for R&D that will lead to production;
  3. The required levels of accuracy and repeatability; and
  4. Area constraints for both the R&D and the production processes.
 
 
jost

natoli
 
More Questions and Answers
 
Sticking and picking in tablet design, part 1
 
Q: What factors should we consider to eliminate sticking and picking in tablet production?
 
A: Kevin Queensen, Natoli Engineering, says:
 
imageSticking and picking issues are often not detected until a drug product transfers from R&D to production. With sticking being a common problem for tablet manufacturers, you should anticipate solutions to it before you finalize your tablet design, prior to scale-up and full-scale production.
 
 
 
nilfisk

vacumax
 
In Tablets & Capsules magazine
 
Developing pediatric dosage forms
 
William Wei Lim Chin, Pascale Clement, and Uwe Hanenberg, Catalent Pharma Solutions
 
While tablets and capsules are often the preferred dosage forms of both patients and pharmaceutical companies, they can be difficult to swallow for children. This article presents the challenges associated with developing pediatric solid oral dosage forms (SODFs), discusses some alternatives, and describes efforts to develop more patient-centric pediatric drug products.
 
When developing a pediatric-focused drug product, pharmaceutical companies are faced with additional challenges than when developing a product for adults. It's insufficient merely to think of children as small adults and scale the dose down based on a child's body weight. A pediatric dosage form must be safe, effective, palatable, and easy to administer. It must minimize dosing frequency and allow sufficient flexibility to meet children's needs at various stages of development. Also, it's critical that the product be an appropriate size for a child to swallow safely. If a tablet or capsule is too large, the child could choke on it, and if it's too small, the child could aspirate the product into her lungs. Obviously, both of these situations are potentially very dangerous.
 
To learn more about this topic, you can read the article "Developing pediatric dosage forms." You can also find articles listed under "Dosage form" and "Outsourcing" in Tablets & Capsules' Article Archive.
 
 
recro

kikusui
 
Industry news
 
 
 
 
 
 
 
 
 
camfilapc

jrs pharma
 
Supplier news
 
 
 
To find more information about equipment suppliers at the Tablets & Capsules website, click here.
 
 
tc
 
Events and continuing education
 
 
 
 
 
 
 
 
 
 
 
 
 
 
To find more events and continuing education opportunities at the Tablets & Capsules website, click here.
 
July 22, 2019
 
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Supplier Resources
click below for more info
 
camfil
 
kikusui
 
vacumax
 
recro
 
nilfisk
 
natoli
 
jrs pharma
 
jost
 
wilson
 
gelita
 
Supplier Directory
 
Capsule Filling Equipment
Vac-U-Max

Coating
(Equipment & Coatings)

JRS Pharma

Contract Formulation/
Manufacturing & Packaging

Recro Gainesville

Conveying/Mechanical
VAC-U-MAX

Dedusters
Natoli Engineering

Dust Collectors/Filters
Camfil APC
Nilfisk Industrial Vacuums
VAC-U-MAX

Excipients
Gelita
Jost Chemical
JRS Pharma

Feeders
VAC-U-MAX

Inspection Equipment
Natoli Engineering

Lifters
VAC-U-MAX

Metal Detectors/X-Ray Detectors
Natoli Engineering

Mixers & Blenders
VAC-U-MAX

Pneumatic Conveying
Nilfisk Industrial Vacuums
VAC-U-MAX

Services
Natoli Engineering
VAC-U-MAX
Wilson Tool

Storage/Bulk Handling
VAC-U-MAX

Tablet Presses
Kikusui USA Inc.
Natoli Engineering

Testing Equipment
Natoli Engineering

Tooling
Natoli Engineering
Wilson Tool

Vacuum Cleaners
Nilfisk Industrial Vacuums
VAC-U-MAX

Weighing Equipment
VAC-U-MAX
 
T&C Solid Dosage Sourcebook
 
sourcebook

Send your feedback or questions to Peggy Wright at pwright@cscpub.com.
Peggy Wright
T&C Solid Dose Digest
Editor
pwright@cscpub.com
 
Kyle Myers
T&C Solid Dose Digest
Circulation
kmyers@cscpub.com
 
Kurt Beckman
T&C Solid Dose Digest
Designer
kbeckman@cscpub.com
 
Nate Todd
Tablets & Capsules
Editor
ntodd@cscpub.com
 
 
 
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