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Tablets & Capsules SDD
imageIn this issue of T&C Solid Dose Digest:
 
 
 
 
 
 
 
 
kikusui

camfilapc
 
Ask an Expert
 
Excipients and continuous manufacturing
 
Q: How can an improved understanding of excipients and APIs maximize our chances of success in continuous manufacturing?
 
 
Continuous manufacturing of pharmaceutical finished products is now a reality. At this time, pharmaceutical companies are using continuous processes to manufacture four drug products licensed in the US and Europe. They are all oral solid dosage forms. One drug product was a conversion from a batch process; the other three used continuous methods from the outset.
 
 
 
gelita

wilson
 
More Questions and Answers
 
Direct compression tablet lubricants
 
Q: Can a direct compression tablet lubricant act as a dry binder to increase tablet hardness?
 
 
To form a durable compact in the manufacture of a directly compressible tablet, you must physically compress, under relatively high pressure, a homogenized blend of powders, including any active pharmaceutical ingredients (APIs) and any excipients necessary to the tablet's function or suitable manufacture. Compaction is the process, while compression describes the reduction in the volume of powder that occurs during compaction.
 
 
 
jost

natoli
 
In Tablets & Capsules magazine
 
Lactose-free reformulation of cetirizine tablets
 
Hanna Bogner and Gernot Warnke, JRS Pharma
 
In this article, researchers present the results of a study that examined how dextrates can replace lactose in cetirizine tablets for the benefit of lactose-intolerant patients.
 
Cetirizine dihydrochloride is a second-generation antihistamine that is used to treat hay fever, allergies, angioedema, and urticaria (hives). As an H1 antagonist, cetirizine relieves the symptoms of allergic reactions by temporarily blocking the action of histamine at the H1 receptors [1,2]. Cetirizine is one of the most common H1 antihistamines, but many cetirizine tablets on the market contain lactose, making them unsuitable for lactose-intolerant patients [3].
 
Approximately 33 percent of the global population is affected by lactose intolerance—the inability to digest the milk sugar lactose. This condition is caused by a shortage of the enzyme lactase, which can lead to several gastrointestinal symptoms, including abdominal pain, bloating, diarrhea, gas, and nausea. Almost all infants produce sufficient amounts of lactase, but about 75 percent of adults have impaired lactase activity, especially in large parts of Asia and Africa. For this reason, it's important to study alternative excipients for the development of lactose-free drug products [4,5].
 
To learn more about this topic, you can read the article "Eye on excipients: Lactose-free reformulation of cetirizine tablets." You can also find articles under "Excipients" and "Formulation" Tablets & Capsules' Article Archive.
 
 
nilfisk

vacumax
 
Feature
 
Flashing during tablet compression, part 2
 
Q: What causes protrusions around the edge of tablets after compression, and how can I prevent this from occurring?
 
imageA: Mike Beyl, Wilson Tool International, says:
 
In part 1 of this series, I explained that the protrusions that form along the tablet band during compression are called flashing, discussed flashing's impacts and causes, and recommended investing in a setting tool that can reduce tablet-press setup time and achieve a more consistent alignment of the upper punch in the die bore. In this installment of this series, I'll discuss how proper tablet and tooling design can help minimize flashing.
 
 
 
recro

tc
 
PBE Solids Handling Conference
 
imageThe PBE Solids Handling Conference will occur September 18-19 at the New Jersey Convention Center in Edison, NJ. At no cost, an admission package can connect you with leading suppliers and offer you access to free education on the center stage while networking with new partners and other industry professionals. The conference also features technical workshops that provide professional development hours (PDH).

Register today for the upcoming 2019 PBE Solids Handling Conference
 
 
Industry news
 
 
 
 
 
 
Supplier news
 
 
 
 
To find more information about equipment suppliers at the Tablets & Capsules website, click here.
 
Events and continuing education
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
To find more events and continuing education opportunities at the Tablets & Capsules website, click here.
 
June 10, 2019
 
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Supplier Resources
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Supplier Directory
 
Capsule Filling Equipment
Vac-U-Max

Contract Formulation/
Manufacturing & Packaging

Recro Gainesville

Conveying/Mechanical
VAC-U-MAX

Dedusters
Natoli Engineering

Dust Collectors/Filters
Camfil APC
Nilfisk Industrial Vacuums
VAC-U-MAX

Excipients
Gelita
Jost Chemical

Feeders
VAC-U-MAX

Inspection Equipment
Natoli Engineering

Lifters
VAC-U-MAX

Metal Detectors/X-Ray Detectors
Natoli Engineering

Mixers & Blenders
VAC-U-MAX

Pneumatic Conveying
Nilfisk Industrial Vacuums
VAC-U-MAX

Services
Natoli Engineering
VAC-U-MAX
Wilson Tool

Storage/Bulk Handling
VAC-U-MAX

Tablet Presses
Kikusui USA Inc.
Natoli Engineering

Testing Equipment
Natoli Engineering

Tooling
Natoli Engineering
Wilson Tool

Vacuum Cleaners
Nilfisk Industrial Vacuums
VAC-U-MAX

Weighing Equipment
VAC-U-MAX
 
T&C Solid Dosage Sourcebook
 
sourcebook

Send your feedback or questions to Peggy Wright at pwright@cscpub.com.
Peggy Wright
T&C Solid Dose Digest
Editor
pwright@cscpub.com
 
Kyle Myers
T&C Solid Dose Digest
Circulation
kmyers@cscpub.com
 
Kurt Beckman
T&C Solid Dose Digest
Designer
kbeckman@cscpub.com
 
Nate Todd
Tablets & Capsules
Editor
ntodd@cscpub.com
 
 
 
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