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Tablets & Capsules SDD
imageIn this issue of T&C Solid Dose Digest:
 
 
 
 
 
 
 
camfilapc

gelita
 
In Tablets & Capsules magazine
 
Containing hazardous compounds in tableting operations
 
Matt Bundenthal, Fette Compacting America, say:
 
As pharmaceutical manufacturers develop and produce increasing numbers of highly potent active pharmaceutical ingredients (HPAPIs), they also must maintain worker safety. Depending on the level of safety required, companies must often make additional facility and engineering accommodations, including provisions for water, air handling, dust collection, feeding, and discharging.
 
Selecting a tableting system for HPAPI applications requires many choices and involves an array of potentially confusing terms and acronyms. For example, the terms wash-in-place (WIP) and clean-in-place (CIP) are very similar, but WIP usually requires some level of disassembly and manual cleaning, while CIP implies a more fully automated process with little or no disassembly. While CIP can greatly mitigate the risk of inhaling hazardous compounds, it's generally not practical for cleaning a tablet press, because some areas inside the press can't be fully cleaned while the press is assembled.
 
To learn more about this topic, you can read the article "Containing hazardous compounds in tableting operations." You can also find articles under "High-potency manufacturing" and "Tablets and tabletting" in Tablets & Capsules' Article Archive.
 
 
wilson

jost
 
More Questions and Answers
 
Vacuum conveying for tablet press operations
 
Q: How can I reduce manual handling and spillage of my tablet formulation?
 
A: Doan Pendleton, Vac-U-Max, says:
 
imageIn pharmaceutical tableting, as production demands increase and you add new tablet presses, you must change your methods of loading and unloading them. Historically, operators have hand-scooped excipients and APIs from drums into surge bins located on the tablet press. This can lead to considerable spillage around the press and result in potential combustible-dust hazards and hygiene issues. Equally important is the danger of the surge bin running dry, resulting in damage to the expensive tablet press tooling.
 
 
 
natoli

nilfisk
 
Feature
 
DNA molecular taggants: A hidden key to pharmaceutical patient safety
 
 
Counterfeit drug products are a major problem for the pharmaceutical industry. This article discusses how DNA molecular taggants can help combat drug counterfeiting and improve the safety of the pharmaceutical supply chain.
 
The pharmaceutical industry has always been at the forefront of safety practices given the potentially dire consequences of a breach in product purity. Still, counterfeit drug products remain a growing problem [1]. Technologies that enable drug counterfeiting, adulteration, and diversion are becoming more accessible, accurate, and affordable, and online buying offers anonymous worldwide distribution. As it becomes easier to replicate the look and feel of a popular tablet or capsule and mimic the graphics and serialization on a package, the stakes have never been higher.
 

 
For more information on this topic, you can read the article "DNA molecular taggants: A hidden key to pharmaceutical patient safety," by Judy Murrah, Applied DNA Sciences. You can also find articles listed under "Anti-counterfeiting" in Tablets & Capsules' Article Archive.
 
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recro
 
Industry news
 
 
 
 
 
 
 
 
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tc
 
Supplier news
 
 
To find more information about equipment suppliers at the Tablets & Capsules website, click here.
 
Events and continuing education
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
February 11, 2019
 
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Supplier Resources
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Supplier Directory
 
Capsule Filling Equipment
Vac-U-Max

Contract Formulation/
Manufacturing & Packaging

Recro Gainesville

Conveying/Mechanical
VAC-U-MAX

Dedusters
Natoli Engineering

Dust Collectors/Filters
Camfil APC
Nilfisk Industrial Vacuums
VAC-U-MAX

Excipients
Gelita
Jost Chemical

Feeders
VAC-U-MAX

Inspection Equipment
Natoli Engineering

Lifters
VAC-U-MAX

Metal Detectors/X-Ray Detectors
Natoli Engineering

Mixers & Blenders
VAC-U-MAX

Pneumatic Conveying
Nilfisk Industrial Vacuums
VAC-U-MAX

Services
Natoli Engineering
VAC-U-MAX
Wilson Tool

Storage/Bulk Handling
VAC-U-MAX

Tablet Presses
Kikusui USA Inc.
Natoli Engineering

Testing Equipment
Natoli Engineering

Tooling
Natoli Engineering
Wilson Tool

Vacuum Cleaners
Nilfisk Industrial Vacuums
VAC-U-MAX

Weighing Equipment
VAC-U-MAX
 
T&C Solid Dosage Sourcebook
 
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Send your feedback or questions to Peggy Wright at pwright@cscpub.com.
Peggy Wright
T&C Solid Dose Digest
Editor
pwright@cscpub.com
 
Judie Hadley
T&C Solid Dose Digest
Circulation
jhadley@cscpub.com
 
Kurt Beckman
T&C Solid Dose Digest
Designer
kbeckman@cscpub.com
 
Nate Todd
Tablets & Capsules
Editor
ntodd@cscpub.com
 
 
 
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