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Tablets & Capsules SDD
imageIn this issue of T&C Solid Dose Digest:
 
 
 
 
 
 
 
nilfisk

kraemer
 
Ask an Expert
 
Jet milling
 
Q: What are the benefits of jet milling for solid dosage manufacturing?
 
 
imageWell-designed, high-speed mechanical mills can grind some friable materials into the low-micron range, but wear and product contamination are serious problems, as is attritional heat. Practically, the minimum target particle size for a high-speed mechanical mill, such as a hammer mill, is 200 mesh (74 microns), with a typical mid-range of 80 mesh (177 microns). Abrasive products can seriously erode most hammer mills, adding metallic contamination to a product. The heat generated in hammer mills can cause problems for materials that degrade with heat or have low melting temperatures.
 
 
 
natoli

vacumax
 
More Questions and Answers
 
Capping and lamination
 
Q: How can I prevent capping and lamination in my tablets?
 
A: Jonathan Gaik, Natoli Engineering, says:
 
imageimageCapping and lamination are common defects that occur during tablet manufacturing. Capping happens when the upper or lower part of a tablet separates horizontally (photo) as the press ejects the tablet. Lamination is separation that occurs at any other part of the tablet except the top or bottom. A cross-section of a tablet without capping or lamination shows that the structure is continuous in appearance, while a cross-section of tablets with the potential to cap or laminate shows a discontinuous structure or visible, localized defects that you can see either with the naked eye or a scanning electron microscope (SEM).
 
 
 
kikusui

jrs
 
Feature
 
Advances in manufacturing liquid-filled hard and soft capsules for delivery of difficult APIs
 
 
Capsules filled with liquids or semisolids offer a greater range of formulation options than other dosage forms do, particularly when the active pharmaceutical ingredient (API) is lipophilic, poorly bioavailable, or highly potent. This article highlights advances in the design and production of liquid-filled hard capsules and summarizes how they perform compared to liquid-filled soft gelatin capsules.
 
Combinatorial chemistry and high-throughput screening have led to the discovery of many drug candidates that are difficult to deliver using traditional tablets or capsules. Many are highly lipophilic and have high molecular weights [1]. Consequently, they likely have poor solubility in aqueous solutions, and hence, low and variable bioavailability [2, 3]. The physicochemical properties of peptide and protein-like macromolecules also pose problems for oral administration [4].
 
 
jost

alfacaps
 
Industry news
 
 
 
 
 
 
 
camfilapc

recro
 
Supplier news
 
 
 
 
 
 
 
To find more information about equipment suppliers at the Tablets & Capsules website, click here.
 
November 26, 2018
 
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Supplier Resources
click below for more info
 
kraemer
 
natoli
 
nilfisk
 
camfil
 
jrs
 
jost
 
jrs
 
recro
 
kikusui
 
vacumax
 
Supplier Directory
 
Capsule Filling Equipment
Alfacaps

Coating(s) & Equipment
JRS Pharma

Contract Formulation/ Manufacturing & Packaging
Recro Gainesville

Conveying/Mechanical
VAC-U-MAX

Dedusters
Kraemer
Natoli Engineering

Dust Collectors/Filters
Camfil APC
Nilfisk Industrial Vacuums
VAC-U-MAX

Empty Capsules
Alfacaps

Excipients
Jost Chemical
JRS Pharma

Feeders
VAC-U-MAX

Inspection Equipment
Kraemer
Natoli Engineering

Metal Detectors/X-Ray Detectors
Natoli Engineering

Pneumatic Conveying
Nilfisk Industrial Vacuums
VAC-U-MAX

Services
Natoli Engineering

Storage/Bulk Handling
VAC-U-MAX

Tablet Presses
Kikusui USA Inc.
Natoli Engineering

Testing Equipment
Natoli Engineering

Tooling
Natoli Engineering

Vacuum Cleaners
Nilfisk Industrial Vacuums

Weighing Equipment
VAC-U-MAX
 
T&C Solid Dosage Sourcebook
 
sourcebook
Events and continuing education
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Send your feedback or questions to Peggy Wright at pwright@cscpub.com.
Peggy Wright
T&C Solid Dose Digest
Editor
pwright@cscpub.com
 
Judie Hadley
T&C Solid Dose Digest
Circulation
jhadley@cscpub.com
 
Kurt Beckman
T&C Solid Dose Digest
Designer
kbeckman@cscpub.com
 
Nate Todd
Tablets & Capsules
Editor
ntodd@cscpub.com
 
 
 
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