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Tablets & Capsules SDD
imageIn this issue of T&C Solid Dose Digest:
 
 
 
 
 
 
 
alfacaps

camfilapc
 
In Tablets & Capsules magazine
 
Abuse-deterrent formulation technologies: Opportunities and limitations
 
Alyn McNaughton, Lonza
 
Too many Americans are misusing or abusing prescription opioids. This article summarizes recent FDA initiatives in this area and assesses the technologies manufacturers have adopted to curb abuse. It concludes with a description of how the author's company developed a capsule-based, abuse-deterrent formulation of levorphanol.
 
Abuse of opioid painkillers in the US is a major problem contributing to an escalating drug overdose epidemic. According to the US Department of Health & Human Services, 12.5 million people misused prescription opioids in 2015, with 2.1 million misusing them for the first time. As a consequence, 33,091 people died from overdosing on opioids, and more than 22,000 of these cases involved prescription opioids. A 2016 study estimated that, in 2013, the economic burden of prescription opioid overdose, misuse, and addiction cost $78.5 billion [1].
 
Since 1999, the volume of drug products prescribed and sold in the US has nearly quadrupled, and the rates of overdose deaths and of admissions to treat substance-abuse disorders related to prescription pain relievers have increased in parallel [2].
 

To learn more about this topic, you can read the article "Abuse-deterrent formulation technologies: Opportunities and limitations." You can also find articles under "Capsules and capsule filling" and "Formulation" in Tablets & Capsules' Article Archive.
 
 
recro

nilfisk
 
More Questions and Answers
 
Wash-in-place tablet dedusters
 
Q: What factors should we consider when purchasing a wash-in-place or clean-in-place tablet deduster?
 
A: Andre Petric, Kraemer US, says:
 
Tablet dedusters are available in non-dust-tight, dust-tight, wash-in-place (WIP), and clean-in-place (CIP) versions.
 
Non-dust-tight. The most common type, non-dust-tight dedusters have gaps around them that can allow dust to escape during operation, especially when dust-collection air volume is lacking. Non-dust-tight machines require disassembly for cleaning, which exposes the operator or cleaning personnel to airborne powders.
 
 
kraemer

natoli
 
Feature
 
Forecasting faster fixes for sticking problems
 
Rob Blanchard, I Holland says:
 
 
Tablet sticking is one of the most common problems in tablet manufacture. This build-up of granules on the punch tip face has a negative effect on tablet appearance and requires more frequent removal of tablet tooling from production for cleaning and maintenance, which increases tablet-press downtime and reduces tablet output.
 
 
vacumax

kikusui
 
Industry news
 
 
 
 
 
jrs

jost
 
Supplier news
 
 
 
 
To find more information about equipment suppliers at the Tablets & Capsules website, click here.
 
October 8, 2018
 
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Supplier Resources
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recro
 
kikusui
 
vacumax
 
kraemer
 
natoli
 
nilfisk
 
camfil
 
jrs
 
jost
 
jrs
 
Supplier Directory
 
Capsule Filling Equipment
Alfacaps

Coating(s) & Equipment
JRS Pharma

Contract Formulation/ Manufacturing & Packaging
Recro Gainesville

Conveying/Mechanical
VAC-U-MAX

Dedusters
Kraemer
Natoli Engineering

Dust Collectors/Filters
Camfil APC
Nilfisk Industrial Vacuums
VAC-U-MAX

Empty Capsules
Alfacaps

Excipients
Jost Chemical
JRS Pharma

Feeders
VAC-U-MAX

Inspection Equipment
Kraemer
Natoli Engineering

Metal Detectors/X-Ray Detectors
Natoli Engineering

Pneumatic Conveying
Nilfisk Industrial Vacuums
VAC-U-MAX

Services
Natoli Engineering

Storage/Bulk Handling
VAC-U-MAX

Tablet Presses
Kikusui USA Inc.
Natoli Engineering

Testing Equipment
Natoli Engineering

Tooling
Natoli Engineering

Vacuum Cleaners
Nilfisk Industrial Vacuums

Weighing Equipment
VAC-U-MAX
 
T&C Solid Dosage Sourcebook
 
sourcebook
Events and continuing education
 
 
 
 
 
 
 
 
 
 
 
 
To find more events and continuing education opportunities at the Tablets & Capsules website, click here.
 
Send your feedback or questions to Peggy Wright at pwright@cscpub.com.
Peggy Wright
T&C Solid Dose Digest
Editor
pwright@cscpub.com
 
Judie Hadley
T&C Solid Dose Digest
Circulation
jhadley@cscpub.comn
 
Kurt Beckman
T&C Solid Dose Digest
Designer
kbeckman@cscpub.com
 
Nate Todd
Tablets & Capsules
Editor
ntodd@cscpub.com
 
 
 
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