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Tablets & Capsules SDD
imageIn this issue of T&C Solid Dose Digest:
 
 
kikusui

jrs
 
Ask An Expert
 
Addressing the needs of the geriatric population
 
Q: What role can excipients and dosage forms play in addressing the challenges of treating geriatric patients?
 
imageA: Alen Guy, IMCD Group says:
 
We're all getting older, of course, but worldwide the percentage of people aged 65 and older will grow from 528 million in 2010 to about 1.47 billion in 2050 [1]. Furthermore, people in that age cohort, who now use 30 to 50 percent of prescriptions, will use 60 to 90 percent of them by 2050 [1]. That makes sense when you consider that someone 55 years old has, on average, 2.68 chronic conditions [2]. By the time this person is older than 65, the average reaches 5 chronic conditions [3]. In addition, nearly 40 percent of the elderly suffer from arthritis and another serious health condition, such as cardiovascular disease or diabetes [4].
 
 
Do you have a question for our experts? Send your questions to pwright@cscpub.com, and we'll have an expert answer them.
 
jost

alfacaps
 
More Questions and Answers
 
Dust containment for tablet manufacturing
 
Q: What should my company look for in a dust containment system?
 
imageA: Luca Di Siervi, Nilfisk says:
 
High-potency APIs (HPAPIs) continue to be one of the fastest-growing segments in pharma. According to a recent report by Grand View Research, the global market for HPAPIs will reach 34.8 billion by 2025 [1].
 
Because HPAPIs are highly toxic, they require a higher level of containment to keep operators safe and also prevent cross-contamination. As a result, my company has seen a growing number of requests for dust containment systems as opposed to the standard filter systems commonly used in the production of less-toxic pharmaceuticals.
 
 
 
camfilapc

nilfisk
 
In Tablets & Capsules magazine
 
Effect of HPC molecular weight on granules and tablets prepared by two wet granulation methods
 
Berna Ehlig, Edmont Stoyanov, and Wade Tanev, Nisso
 
In this article, researchers from Nisso present the results of a study that examined how the molecular weight (MW) of different hydroxypropyl cellulose (HPC) grades affected the characteristics of granules and tablets prepared by two wet granulation methods: high shear and fluid bed.
 
Wet granulation is one of the most commonly used methods of developing solid dosage drug products. Among the advantages of this classical granulation method over other technologies are a narrow particle size distribution (PSD) of the granules, few fine particles that yield little dust, more consistent powder flow, better control of granule size, very good binder homogeneity, and good powder compactability.
 
The most important excipient group in a successful wet granulation formulation is the binder. Within this group are polymers with different chemistries, mechanical properties, and viscosity ranges. The polymer binder HPC has attracted the attention of formulators in the last decade due to its superior mechanical properties, chemical stability, and multi-functionality. This cellulosic ether appears to work even in challenging formulations with high-dose, poorly compressible drug products, where other binders usually fail. Low-viscosity (low-MW) HPC grades are used as a binder for all types of wet granulation including high-shear, fluid-bed, extrusion, and melt granulation. To select the suitable grade, scientists often must conduct many experiments, adjusting the desired powder and tablet characteristics. In this study, we focused on the influence of the HPC MW on the granule and tablet characteristics in fluid-bed and high-shear wet granulation.
 
To learn more about this topic, you can read the article "Effect of HPC molecular weight on granules and tablets prepared by two wet granulation methods." You can also find articles under "Excipients" and "Granulation" in Tablets & Capsules' Article Archive.
 
 
natoli

vacumax
 
Feature
 
Economical multiparticulates
 
Brian Jensen, Freund-Vector
 
Multiparticulates add important functions to solid dosage formulations. They provide reliable drug delivery, reduce the potential for abuse, and supply a platform for high-potency combination products. Made using conical rotor technology, these very small beads can also carry a large amount of API. That allows a given dose to be delivered in small tablets and capsules, which promotes patient compliance. Compact API loading also facilitates combination products because it allows two or more APIs to fit in an envelope that previously could hold just one. Conical rotor technology offers an economical method of producing multiparticulates.
 
For more information on this topic, you can read the article "Back Page: Economical multiparticulates." by Brian Jensen, Freund-Vector. You can also find articles listed under "Formulation" and "Tablet coating" in Tablets & Capsules' Article Archive.
 
 
jost

jost
 
Register today for the upcoming 2018 PBE Southeast Powder Show™ & Conference
 
imageRegister by August 31 to receive discount pricing on the 2018 PBE Southeast Powder Show's™ conference program. It is the only dedicated powder and bulk solids show for North America in 2018 and will be held September 25-27 at the Charlotte Convention Center in Charlotte, NC. To learn more and to register, click here.
 
 
Industry news
 
 
 
 
March 26, 2018
 
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Supplier Resources
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Supplier Directory
 
Capsule Filling Equipment
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Send your feedback or questions to Peggy Wright at pwright@cscpub.com.
Peggy Wright
T&C Solid Dose Digest
Editor
pwright@cscpub.com
 
Kurt Beckman
T&C Solid Dose Digest
Designer
kbeckman@cscpub.com
 
Judie Hadley
T&C Solid Dose Digest
Circulation
jhadley@cscpub.com
 
 
 
 
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