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3D printing of pharmaceuticals
Q: How has 3D printing of solid oral dosage pharmaceuticals advanced in recent years?
The paradigm has shifted for pharmaceutical 3D printing (3DP), also known as additive manufacturing (AM). As with any transformational technology, we often overestimate the frequency of its need. But we equally underestimate its potential impact until we see sufficient proof.
Recently, 3DP has become an increasingly important part of the conversation in pharmaceutical manufacturing because the industry has much more evidence of its benefits. Its application for pharmaceutical manufacturing now appears inevitable.
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Cracks and fractures in capsules
Q: What causes cracks and fractures in capsules?
Pharmaceutical manufacturers who have problems with cracks and fractures generally blame them on brittle capsules received from the capsule supplier. Although that's a possible explanation, suppliers test for moisture and brittleness before releasing lots. Often the damage occurs during shipping and offloading, warehouse storage, or handling in the capsule-filling room.
In Tablets & Capsules magazine
Water activity and moisture: The complexity and interrelationships explained
P. H. M. Janssen, R. J. Blezard, and B. H. J. Dickhoff, DFE Pharma
Water activity and moisture content both represent a measure of water in a material. While the terms are often confused with each other, they are two very different parameters, and understanding the difference can be important for the development of robust pharmaceutical formulations. This article evaluates the two parameters and discusses their relevance for the stability of solid dosage formulations.
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