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Tailored granulation for smart manufacturing
 
Q: How can we use granulation to solve tableting challenges?
 
 
imageWet granulation—an important operation in the pharmaceutical, nutraceutical, and food industries—uses various technologies to convert powders into granules suitable for tablet compression. Powders vary greatly, and tableting processes have a large number of critical process parameters. By investigating these parameters using a Quality by Design approach, you can tailor your granulation process to produce a formulation that is well-suited to high-speed, production-scale tablet presses. The following are some examples of how you can address tableting problems by adjusting your granulation process.
 
 
 
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Using direct torque measurement to achieve precise endpoint determination in high-shear mixer granulation
 
A: Rahul Aware and Vasant Shetty, ACG
 
This article discusses the advantages and disadvantages of different methods for determining the endpoint in a high-shear mixer granulation process and highlights the high-precision direct torque measurement technique.
 
 
You can also find articles under "Granulation" in Tablets & Capsules' Article Archive.
 
 
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In Tablets & Capsules magazine
 
Using near-infrared spectroscopy and chemometric modeling to simultaneously determine ibuprofen and caffeine concentration in softgels
 
Jose Acosta, Sofia Pareja, Dahgna Paez, Jefferson Castro, and Freddy Barrios, Procaps and Jorge Ropero, Universidad del Atlántico
 
This article summarizes a method for rapid and accurate determination of API concentration in the fill of soft gelatin capsules with little or no sample preparation. Applying chemometric models to near-infrared spectrum data allows scientists to predict the API content in samples from the manufacturing process and the final product
 
 
You can also find articles under "Analytical techniques" and "Softgels" in Tablets & Capsules' Article Archive.
 
 
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January 11, 2021
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Send your feedback or questions to Peggy Wright at pwright@cscpub.com.
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