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Tablets & Capsules SDD
imageIn this issue of T&C Solid Dose Digest:
 
 
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vacumax
 
Ask An Expert
 
Filtration for pharmaceutical processing
 
Q: What filtration do we require in solid dosage processing, and where should we locate those filtration steps?
 
 
It's essential to preserve the quality of gas, compressed air, steam, and liquids in solid dosage processing. Compressed air dries sterilized equipment, is sometimes used to move ingredients through lines, and for semi-liquid (gel) formulations, protects liquids in storage tanks. Organisms that make their way into these areas can quickly multiply downstream, compromising the safety of your product.
 
 
Do you have a question for our experts? Send your questions to pwright@cscpub.com and we'll have an expert answer it.
 
kikusui

gamlen
 
More Questions and Answers
 
Predicting properties of production tablets
 
Q: How can we predict the properties of production tablets from small-scale manufacture?
 
imageA: Michael Gamlen, Gamlen Instruments and Joe Domingue, SciMark International, say:
 
Pharmaceutical companies usually develop tablet formulations based on limited information about many parameters, including the drug's dosage and the desired size and shape of the final tablet—round or capsule-shaped, large or small. However, little published data is available that helps formulators to predict the properties of tablets made at one size, during production, based on those of tablets made at another size, during formulation.
 
 
 
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jost
 
In Tablets & Capsules magazine
 
Spotlight on Nutraceuticals: Rough going? Tips for fighting abrasive wear of punches and dies
 
Michael Oxford, I Holland
 
Compressing abrasive nutraceuticals can wear tooling prematurely and cause other problems. This article discusses how wear-resistant tooling steel, anti-abrasive coatings, and good tablet design extend the service life of punches and dies.
 
Manufacturers face several challenges when compressing nutraceutical tablets, many of which are unrefined natural ingredients that are abrasive, corrosive, and/or coarse. It's thus important to determine which material will prolong the service life of compression tooling. As the components most in contact with the product, tablet punches, and dies require robust metallurgy and design.
 
While sticking—the adherence of granules to the punch tip face—can be difficult for pharmaceutical manufacturers to overcome, the ingredients they use are often formulated to improve tablet compression and binding without much physical impact on the tooling. In the nutraceutical industry, it's not so simple.
 
Nutraceutical formulations can contain tens of active ingredients that tend to be bulkier than those used in pharmaceuticals, which makes production problematic. Formulation characteristics like wide variation in particle size, poor compressibility, incompatible ingredients, and moisture sensitivity can also lead to production and tooling issues. To avoid replacing your tooling prematurely and to minimize tablet defects, use punches and dies made from a suitable steel. Also consider adding a coating to the punch tips.
 
To learn more about this topic, you can read the article "Spotlight on Nutraceuticals: Rough going? Tips for fighting abrasive wear of punches and dies." You can also find articles under "Dietary supplements" and "Tooling" in Tablets & Capsules' Article Archive.
 
 
natoli

qualicaps
 
Feature
 
Ideas for de-risking candidate selection
 
 
imageThe rising costs of drug development have led some innovator pharmaceutical companies to scrutinize projects' budgets heavily. As a consequence, timelines for product development have become increasingly aggressive. In some cases, this change has meant paring back or eliminating pre-formulation studies. Although those modifications may reduce costs of development and condense timelines in the short term, significant advantages exist related to those factors if a company invests upfront in knowledge about an active pharmaceutical ingredient's (API's) chemical and physical properties, as the case studies below illustrate.
 
 
 
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jrs
 
Industry news
 
 
 
 
 
 
 
 
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November 27, 2017
 
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Send your feedback or questions to Peggy Wright at pwright@cscpub.com.
Peggy Wright
T&C Solid Dose Digest
Editor
pwright@cscpub.com
 
Kurt Beckman
T&C Solid Dose Digest
Designer
kbeckman@cscpub.com
 
Judie Hadley
T&C Solid Dose Digest
Circulation
jhadley@cscpub.com
 
 
 
 
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